ea0029oc7.5 | Adrenal Clinical | ICEECE2012
Oksnes M.
, Bjornsdottir S.
, Methlie P.
, Bratland E.
, Isaksson M.
, Kampe O.
, Hulting A.
, Bensing S.
, Husebye E.
, Lovas K.
Background: Conventional glucocorticoid replacement therapy is unphysiological, and does not restore quality-of-life in AD. Here we evaluated the dosing regimens and glucocorticoid metabolism in 10 patients undergoing 24 h sampling during oral replacement therapy and CSHI.Design, Subjects, Measurements: We set up a cross-over randomised multi-centre clinical trial to evaluate dosage and effects of CSHI in 40 Scandinavian AD patients, comparing 3 months o...